Yonex 2 MIU (68mg)

Description

Yonex 2 MIU (68mg) IM/IV Injection

Indications
Colistimethate is indicated for the treatment of acute or chronic infections caused by sensitive strains of certain gram-negative bacilli. It is particularly indicated in the infection caused by sensitive strains of Pseudomonas aeruginosa. Colistimethate is not indicated for infections due to Proteus or Neisseria. Colistimethate is very effective in the treatment of infections due to the following gram-negative organisms: Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa.

Composition
Each vial contains Colistimethate Sodium 1 MIU or 34 mg Colistin.
Each vial contains Colistimethate Sodium 2 MIU or 68 mg Colistin.
Each vial contains Colistimethate Sodium 3 MIU or 102 mg Colistin.
Each vial contains Colistimethate Sodium 4.5 MIU or 150 mg Colistin.

Description
Colistimethate sodium is a surface active agent which penetrates into and disrupts the bacterial cell membrane. It has been shown to have bactericidal activity against Aerobic gram-negative microorganisms e.g. Enterobacter aerogenes, E. coli, Klebsiella pneumoniae and Pseudomonas

Pharmacology
Colistimethate is a surface active agent which penetrates into and disrupts the bacterial cell membrane. Colistimethate is polycationic and has both hydrophobic and lipophilic moieties. It interacts with the bacterial cytoplasmic membrane, changing its permeability. This effect is bactericidal. There is also evidence that polymyxins enter the cell and precipitate cytoplasmic components, primarily ribosomes.

Dosage
Maintenance dose: 9 MIU/day in 2-3 divided doses. In patients who are critically ill, a loading dose of 9 MIU should be administered.

Renal impairment patients: Dose adjustments in renal impairment patients are necessary. Dose reductions are recommended for patients with creatinine clearance < 50 ml/min. Twice daily dosing is recommended. Creatinine clearance <50-30 ml/min: daily dose 5.5-7.5 MIU Creatinine clearance <30-10 ml/min: daily dose 4.5-5.5 MIU Creatinine clearance <10 ml/min: daily dose 3.5 MIU Haemodialysis (HD) patients: No-HD days: 2.25 MIU/day (2.2-2.3 MIU/day). HD days: 3 MIU/day (Should be given after the HD session) Twice daily dosing is recommended. Pediatric population: The dose should be based on lean body weight. Children ≤40 kg: 75,000-150,000 IU/kg/day divided into 3 doses. Children >40 kg: >150,000 IU/kg/day has been reported in children with cystic fibrosis.
Hepatic impairment patients: There are no data in patients with hepatic impairment. Caution is advised when administering colistimethate sodium in these patients.