Macrosol

Description

Macrosol 100 ml Syrup

Indications
For use in adults and children over 12 years of age for effective relief from constipation and treatment of chronic constipation. Also effective in resolving fecal impaction, defined as refractory constipation with fecal loading of the rectum and colon.

Composition
Each 25 ml concentrated oral solution contains-
Polyethylene Glycol 3350: 13.125 gm
Sodium Chloride: 350.7 mg
Sodium Bicarbonate: 178.5 mg
Potassium Chloride: 46.6 mg
Each sachet (Powder for Suspension) contains-
Polyethylene Glycol 3350: 13.125 gm
Sodium chloride: 350.7 mg
Sodium Bicarbonate: 178.5 mg
Potassium Chloride BP 46.6 mg.

Pharmacology
Macrogol, also known as polyethylene glycol exerts an osmotic action in the gut, which induces a laxative effect. Macrogol increases stool volume, which triggers colon motility via neuromuscular pathways. The physiological consequence is an improved propulsive colonic transportation of the soften stools and a facilitation of the defecation. Electrolytes combined with Macrogol are exchanged across the intestinal barrier (mucosa) with serum electrolytes and excreted without net gain or loss of sodium, potassium and water. Macrogol is unchanged along the gut. It is virtually unabsorbed from the gastrointestinal tract.

Dosage & Administration
For adults and children aged 12 years and above: (Powder for Suspension)
Constipation: The dose is 1 sachet daily. This may be increased to 2-3 sachets daily, if required.
Fecal Impaction: 8 sachets daily, consumed within 6 hours. A course of treatment for fecal impaction does not normally exceed 3 days.
Patients with renal insufficiency: No dosage change is necessary for treatment of either constipation or fecal impaction.
Direction of use: Each sachet should be dissolved in 125 ml water. For fecal impaction 8 sachets may be dissolved in 1 litre of water. Store the solution refrigerated and discard any solution not used within 6 hours.
For adults and children aged 12 years and above: (Oral Solution)
Constipation: 25 ml of Polyethylene Glycol 3350 and electrolytes oral solution added to 100 ml of water once daily (to make a total volume of 125 ml). This may be increased to 2-3 doses of 25 ml daily (each 25 ml dose added to 100 ml of water), if required according to individual response.
Fecal Impaction: 8 doses of 25 ml daily (each 25 ml dose added to 100 ml of water). A course of treatment for fecal impaction does not normally exceed 3 days.
Direction of use: 25 ml of oral solution added to 100 ml of water (to make a total volume of 125 ml). Any unused diluted solution should be discarded within 24 hours.