Linda-S DS 10 IU

Description

Linda-S DS 10 IU IM/IV Injection

Indications
Oxytocin is indicated in-
Induction of labor, stimulation of uterine contractions.
Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta.
To stimulate lactation, only it advised by the registered Gynaecologist/Physician.
Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage.

Description
The active substance of this preparation is synthetically prepared oxytocin, which is identical to the natural occurring hormone from the posterior pituitary gland. Oxytocin causes contractions of the uterus, thus mimicking contractions of normal, spontaneous labor and transiently impeding uterine blood flow. Amplitude and duration of uterine contractions are increased, leading to dilation and effacement of the cervix. Oxytocin also stimulates the smooth muscle associated with the secretory epithelium of the lactating breast causing ejection of milk out of the mammary ductular system but having no direct effect on milk secretion. Oxytocin has only minimal cardiovascular and antidiuretic properties. Therefore, it can safely be administered to patients in whom a (further) increase in blood pressure must be avoided, as in the case of hypertension, toxaemia, (pre-) eclampsia, solutio placentae and uraemia.

Pharmacology
Uterine motility depends on the formation of the contractile protein actomyosin under the influence of the Ca2+ dependent phosphorylating enzyme myosin light-chain kinase. Oxytocin promotes contractions by increasing the intracellular Ca2+, which in turn activates myosin’s light chain kinase. Oxytocin has specific receptors in the muscle lining of the uterus and the receptor concentration increases greatly during pregnancy, reaching a maximum in early labor at term.

Dosage & Administration
Induction of labor, stimulation of uterine contractions: Oxytocin should be given by intravenous infusion under adequate control, 1-5 IU added to 500 ml of infusion fluid. The administration is started at 1 mU (1 mU=0.001 IU) per minute. According to the effect obtained the dosage can be doubled every 30-45 minutes until the uterus threshold has been attained. A further increase will then usually provide optimal activity. The threshold is generally below 10 mU per minute.

N.B.: Intramuscular administration of Oxytocin may lead to an irregular response and symptoms of overdosage. It intramuscular administration is nevertheless unavoidable, dosage should not exceed 0.5-1 IU per injection.

Post delivery period, for the prevention or treatment of secondary haemorrhage and adherent placenta: Intramuscular injection of 2-5 IU, or as intravenous infusion in an adequate dosage

To stimulate lactation, only it advised by the registered Gynaecologist/Physician: Intramuscular injection of 2 IU

Treatment of incomplete abortion to obtain more rapid expulsion in order to prevent secondary hemorrhage: Intramuscular injection of 2-5 IU every 30-60 minutes or as intravenous infusion in an adequate dosage