Clovir

Description

Clovir 5 gm Cream

Indications
Acyclovir cream is indicated for the treatment of initial and recurrent labial and genital Herpes simplex infections. Treatment should begin as early as possible.

Pharmacology
Aciclovir is a synthetic purine derivative. It exerts its antiviral effect on Herpes simplex virus (HSV) and Varicella zoster virus by interfering with DNA synthesis and inhibiting viral replication. In cells infected with herpes virus, the antiviral activity of Aciclovir
appears to depend principally on the intracellular conversion of the drug to Aciclovir Triphosphate. Aciclovir is converted to Aciclovir Monophosphate principally via virus coded thymidine kinase; the monophosphate is phosphorylated to the diphosphate via cellular guanylate kinase and then via other cellular enzyme to the triphosphate, which is the pharmacologically active form of the drug. Percutaneous absorption of Aciclovir appears to be minimal following topical application of the drug to intact skin.

Dosage & Administration
Acyclovir cream should be applied to lesions 5 times daily for 5-10 days. The affected area should be kept clean and dry; patients should be instructed to wear loose-fitting clothing to avoid irritation to the lesion.

Safety and effectiveness in pediatric patients less than 12 years of age have not been established.