Ansulin N 100 IU

Description

Ansulin N 100 IU Insulin

Indications
Insulin Human Injection is indicated in-
Treatment of all patients with type 1 diabetes
Treatment of patients with type 2 diabetes who are not adequately controlled by diet and/ or oral hypoglycemic agents
For the initial stabilization of diabetes in patients with diabetic ketoacidosis, hyperosmolar non-ketotic syndrome and during periods of stress such as severe infections and major surgery in diabetic patients
Treatment of gestational diabetes.

Pharmacology
This is a sterile, clear, colorless solution of Insulin Human. It is a fast-acting insulin and has a relatively short duration of action as compared with other insulins. It may be used in combination with long-acting insulins. The blood glucose lowering effect of insulin is due to the facilitated uptake of glucose following binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver.

Insulin has a half-life of a few minutes in the blood stream. No profound binding to plasma proteins. An average action profile after subcutaneous injection indicates:
Onset of action- within 30 minutes
Peak plasma levels attained between 1-3 hours
Duration of action- approximately 4-6 hours

Dosage
Dosage is individual and determined by the physician in accordance with the needs of the patient.

The average range of total daily insulin requirement for maintenance therapy in type 1 diabetic patients lies between 0.5 and 1.0 IU/Kg. In pre-pubertal children it usually varies from 0.7 to 1.0 IU/ Kg.

The daily insulin requirement may be higher in patients with insulin resistance (e.g. during puberty in the young or due to obesity) and lower in patients with endogenous insulin production or during the period of partial remission.

Initial dosage for type 2 diabetic patients are often lower, e.g. 0.3 to 0.6 IU/ Kg/ Day.

An injection should be followed within 30 minutes by a meal or snack containing carbohydrates.