Ampexin 250

Description

Ampexin 250 mg Injection

Indications
Ampicillin is indicated in the treatment of infections caused by susceptible strains of the designated organism listed below:
Infections of the Genitourinary Tract Including Gonorrhea: E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, and nonpenicillinase-producing N. gononhoeae.
Infections of the Respiratory Tract: Nonpenicillinase-producing H. influenzae and staphylococci, and streptococci including streptococcus pneumoniae.
Infections of the Gastrointestinal Tract: Shigella, S. typhosa and other Salmonella, E. coli, P. mirabilis, and enterococci.
Meningitis: O. Meningitides.
Bacteriology studies to determine the causative organisms and their sensetivity to ampicillin should be performed. Therapy may be instituted prior to the results of susceptibility testing.

Pharmacology
Ampicillin inhibits bacterial cell wall synthesis by binding to 1 or more of the penicillin-binding proteins (PBPs) which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.

Dosage
Intra-articular:
Supplement in systemic therapy for treatment of susceptible infections-
Adult: 500 mg daily.
Child: <10 yr Half of adult routine dosage. Intraperitoneal: Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily. Child: <10 yr Half of adult routine dosage. Intrapleural: Supplement in systemic therapy for treatment of susceptible infections- Adult: 500 mg daily. Child: <10 yr Half of adult routine dosage Intravenous: Meningitis- Adult: 2 gm 6 hrly. Child: 150 mg/kg daily in divided doses. Intrapartum prophylaxis against group B Streptoccocal infection in neonates- Adult: Initially, 2 gm via IV inj followed by 1 gm 4 hrly until delivery. Oral: Biliary tract infections, Bronchitis, Endocarditis, Gastroenteritis, Listeriosis, Otitis media, Perinatal streptococcal infections, Peritonitis- Adult: 0.25-1 gm 6 hrly. Child: <10 yr Half of adult routine dosage. Typhoid and paratyphoid fever- Adult: 1-2 gm 6 hrly for 2 wk in acute infections, and 4-12 wk in carriers. Uncomplicated gonorrhoea- Adult: 2 gm with 1 gm of probenecid as single dose, recommended to be repeated in female patients. Urinary tract infections- Adult: 500 mg 8 hrly. Parenteral: Susceptible infections- Adult: 500 mg 6 hrly, via IM or slow IV inj over 3-5 min or by infusion. Child: <10 yr Half of adult routine dosage. Septicaemia- Adult: 150-200 mg/kg daily. Initiate with IV admin for at least 3 days, then continue with IM inj 3-4 hrly. Continue treatment for at least 48-72 hr after the patient has become asymptomatic or when there is evidence of bacterial eradication. Recommended treatment duration for infections caused by group-A β-haemolytic streptococci: At least 10-days, to prevent occurrence of acute rheumatic fever or acute glomerulonephritis. Child: Same as adult dose.